Basic Information
| LncRNA/CircRNA Name | LINC00630 |
| Synonyms | NA |
| Region | GRCh38_X:102769161-102885406 |
| Ensemble | ENSG00000223546 |
| Refseq | NR_038988 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Western blot |
| Sample | CRC tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | elevated LINC00630 correlated with radio-resistance and poorer prognosis in CRC. Knockdown of LINC00630 significantly improved the sensitivity of CRC cells to irradiation. Mechanistically, LINC00630 in complex with EZH2 negatively regulated BEX1 through promoter DNA methylation. BEX1 silencing greatly restored the cell viability and suppressed cell apoptosis, which were elicited by LINC00630 deficiency in response to irradiation. |
| Pubmed ID | 32119177 |
| Year | 2020 |
| Title | Long noncoding RNA LINC00630 promotes radio-resistance by regulating BEX1 gene methylation in colorectal cancer cells |
External Links
| Links for LINC00630 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |