Basic Information
| LncRNA/CircRNA Name | LINC00628 |
| Synonyms | NA |
| Region | GRCh38_1:204368431-204369719 |
| Ensemble | ENSG00000280924 |
| Refseq | NR_027022 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Cell proliferation assay, Cell migration and invasion assay etc. |
| Sample | breast cancer tissues, cell lines (LCC9, MDA-MB-231, LCC2 and MCF-7) |
| Expression Pattern | down-regulated |
| Function Description | The relative expression level of LINC00628 in breast cancer tissues and cell lines were significantly decreased. The overexpression of LINC00628 suppressed breast cancer cells proliferation, invasion and migration. Further, with the overexpression of LINC00628, cell cycle was arrested in G0/G1 phase in breast cancer cells and cell apoptosis was promoted. The relative expression of Caspase-3 and Bax protein were significantly increased and the relative expression of Bcl-2 protein was significantly decreased after transfection with LINC00628. |
| Pubmed ID | 28165561 |
| Year | 2017 |
| Title | Long non-coding RNA LINC00628 suppresses the growth and metastasis and promotes cell apoptosis in breast cancer. |
External Links
| Links for LINC00628 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |