Basic Information
| LncRNA/CircRNA Name | LINC00619 |
| Synonyms | NA |
| Region | GRCh38_10:43845306-43850622 |
| Ensemble | ENSG00000204187 |
| Refseq | NR_033923 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | gastric cancer tumor tissues and adjacent normal gastric mucosal tissues,cell lines (SGC-7901, MGC-803, MKN-28, HGC-27,SNU-1,GES-1) |
| Expression Pattern | down-regulated |
| Function Description | Gastric cancer was characterized by downregulation of LINC00619 and OPCML and upregulation of miR-224-5p. Additionally, we found that miR-224-5p could interact with both LINC00619 and OPCML. Upregulation of LINC00619, which binds to miR-224-5p, led to decreased miR-224-5p expression while increasing the expression of OPCML, a target gene of miR-224-5p. |
| Pubmed ID | 32359894 |
| Year | 2020 |
| Title | LINC00619 restricts gastric cancer progression by preventing microRNA-224-5p-mediated inhibition of OPCML. |
External Links
| Links for LINC00619 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |