Basic Information
| LncRNA/CircRNA Name | LINC00617 |
| Synonyms | TUNAR, HI-LNC78, LINC00617, TUNA |
| Region | GRCh38_14:95876392-95925571 |
| Ensemble | ENSG00000250366 |
| Refseq | NR_038861 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, RIP, ChIP, Luciferase reporter assay, RNA pull-down assay etc. |
| Sample | breast cancer tissues, cell lines (MCF7, T47D, BT474, and MDA-MB-468) |
| Expression Pattern | up-regulated |
| Function Description | We found the human ortholog of TUNA, linc00617, was upregulated in breast cancer samples. Linc00617 promoted motility and invasion of breast cancer cells and induced epithelial-mesenchymal-transition (EMT), which was accompanied by generation of stem cell properties. Moreover, knockdown of linc00617 repressed lung metastasis in vivo. We demonstrated that linc00617 upregulated the expression of stemness factor Sox2 in breast cancer cells, which was shown to promote the oncogenic activity of breast cancer cells by stimulating epithelial-to-mesenchymal transition and enhancing the tumor-initiating capacity |
| Pubmed ID | 26207516 |
| Year | 2015 |
| Title | Long noncoding RNA linc00617 exhibits oncogenic activity in breast cancer |
External Links
| Links for LINC00617 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |