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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	glioma
ICD-0-3	NA
Methods	qPCR, Western blot, RIP
Sample	Human normal glia cell line NHA, and glioma cell lines LN18, U87, U251 and U138, Human glioma tissues, Normal brain tissues
Expression Pattern	down-regulated
Function Description	a novel lncRNA LINC00526, which is significantly low expressed in glioma. Low expression of LINC00526 is correlated with aggravation and poor survival in glioma. Functional assays revealed that ectopic expression of LINC00526 inhibits glioma cell prolifera- tion, migration, and invasion. LINC00526 silencing promotes glioma cell proliferation, migration and invasion. Mechanistically, we found that LINC00526 directly interacts with EZH2, represses the binding of EZH2 to AXL promoter, attenuates the transcrip- tional activating roles of EZH2 on AXL, and therefore represses AXL expression.Via re- pressing AXL, LINC00526 further represses PI3K/Akt/NF-?B signalling. Intriguingly, we identified that NFKB1 and NFKB2 directly binds LINC00526 promoter and re- presses LINC00526 transcription. We further found that via activating NF-?B sig- nalling, AXL represses LINC00526 transcription.
Pubmed ID	31240814
Year	2019
Title	Long non-coding RNA LINC00526 represses glioma progression via forming a double negative feedback loop with AXL

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