Basic Information
| LncRNA/CircRNA Name | LINC00520 |
| Synonyms | LINC00520, C14orf34 |
| Region | GRCh38_14:55781135-55796688 |
| Ensemble | ENSG00000258791 |
| Refseq | NR_026796 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RNA-seq, qPCR, RNAi etc. |
| Sample | cell lines (MCF-7, and MDA-MB-468, MDA-MB-453, MDA-MB-231 etc.) |
| Expression Pattern | up-regulated |
| Function Description | LINC00520 is elevated in a subset of human breast carcinomas, with preferential enrichment in the basal-like molecular subtype. ShRNA-mediated depletion of LINC00520 results in decreased cell migration and loss of invasive structures in 3D. |
| Pubmed ID | 27626181 |
| Year | 2016 |
| Title | LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer. |
External Links
| Links for LINC00520 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |