Basic Information
| LncRNA/CircRNA Name | LINC00519 |
| Synonyms | NA |
| Region | GRCh38_14:51304416-51328386 |
| Ensemble | ENSG00000258955 |
| Refseq | NR_145423 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung squamous cell carcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | LUSC and matched adjacent tissue ,cell lines(H266, SK-MES-1) |
| Expression Pattern | up-regulated |
| Function Description | Elevated level of LINC00519 was identified in LUSC tissues and cell lines. High LINC00519 level predicted unsatisfactory prognosis. Then, loss-of-function assays suggested the inhibitive role of silenced LINC00519 in cell proliferation, migration, invasion and tumour growth and promoting effect on cell apoptosis in LUSC. Mechanically, LINC00519 was activated by H3K27 acetylation (H3K27ac). Moreover, LINC00519 sponged miR-450b-5p and miR-515-5p to up-regulate Yes1 associated transcriptional regulator (YAP1). |
| Pubmed ID | 32297697 |
| Year | 2020 |
| Title | H3K27ac-activated LINC00519 promotes lung squamous cell carcinoma progression by targeting miR-450b-5p/miR-515-5p/YAP1 axis. |
External Links
| Links for LINC00519 | GenBank HGNC NONCODE |
| Links for lung squamous cell carcinoma | OMIM COSMIC |