Basic Information
| LncRNA/CircRNA Name | LINC00515 |
| Synonyms | NA |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_024092 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | RT-PCR , Luciferase reporter assay , Western blot , RNAi , in vitro knockdown etc. |
| Sample | glioma tissues and adjacent normal tissues ,Human glioma cell lines??251, U87MG, LN229??nd normal human astrocyte (NHA) cells |
| Expression Pattern | up-regulated |
| Function Description | LINC00515 was up-regulated in glioma tissues and cell lines. LINC00515 was mainly located in the cytoplasm in glioma cells. Knockdown of LINC00515 led to decreased proliferation and increased apoptosis of glioma cells. Mechanistically, there was a LINC00515/miR-16/PRMT5 regulatory axis in glioma. LINC00515 could activate PRMT5 expression and promote glioma progression by acting as a sponge of miR-16.LINC00515 expression is elevated in human glioma and promotes growth and inhibits apoptosis of glioma cells. The regulatory cascade LINC00515/miR-16/PRMT5 plays a critical role in glioma progression. |
| Pubmed ID | 31114220 |
| Year | 2019 |
| Title | Long Noncoding RNA LINC00515 Promotes Cell Proliferation and Inhibits Apoptosis by Sponging miR-16 and Activating PRMT5 Expression in Human Glioma |
External Links
| Links for LINC00515 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |