Basic Information
| LncRNA/CircRNA Name | LINC00511 |
| Synonyms | LINC00511, LCAL5, onco-lncRNA-12 |
| Region | GRCh38_17:72323123-72640472 |
| Ensemble | ENSG00000227036 |
| Refseq | NR_033876 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, Cell proliferation assay etc. |
| Sample | lung cancer tissues, cell line (A549) |
| Expression Pattern | up-regulated |
| Function Description | We detected 6 lncRNAs including 3 that were up-regulated (LINC00511, AFAP1-AS1, CASC9) and 3 down-regulated (LINC00968, TINCR, LINC00035) in 20 paired LUAD and LUSC and normal tissues to evaluate the analysis results. The results of qPCR showed that all the chosen lncRNA expressions were increased or decreased in LUAD or LUSC tissues compared with those in the normal tissues, which is consistent with the bioinformatic analysis results. Knockdown of LINC00511, AFAP1-AS1, and PVT1 impaired LUAD or LUSC cell proliferation. |
| Pubmed ID | 27797003 |
| Year | 2016 |
| Title | Transcriptome analysis of distinct long non-coding RNA transcriptional fingerprints in lung adenocarcinoma and squamous cell carcinoma. |
External Links
| Links for LINC00511 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |