Basic Information
| LncRNA/CircRNA Name | LINC00511 |
| Synonyms | NA |
| Region | GRCh38_17:72323123-72640472 |
| Ensemble | ENSG00000227036 |
| Refseq | NR_033876 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, etc. |
| Sample | osteosarcoma tissues, Human osteosarcoma cell lines (MG-63, Saos-2, U2OS, and HOS) and one normal osteoblast cell line (NHOst) |
| Expression Pattern | up-regulated |
| Function Description | the expression of Linc00511 was upregulated in osteosarcoma samples and cell lines. Ectopic expression of Linc00511 promoted osteosarcoma cell growth, colony formation, and migration. Moreover, overexpression of Linc00511 enhanced the epithelial mesenchymal transition progression in osteosarcoma cell. In addition, we showed that elevated expression of Linc00511 suppressed microRNA 765 (miR 765) expression and promoted apurinic/apyrimidinic endonuclease 1 (APE1) expression in osteosarcoma cell. The expression of miR 765 was downregulated in osteosarcoma cells and samples and was negatively related to Linc00511 expression in osteosarcoma tissues. Ectopic expression of miR 765 inhibited osteosarcoma cell growth and migration. Furthermore, we showed that Linc00511 overexpression promoted MG 63 cells proliferation, colony formation, and migration via downregulation of miR 765. These results suggested that Linc00511 played as an oncogene in the development of osteosarcoma. |
| Pubmed ID | 30592325 |
| Year | 2018 |
| Title | LncRNA Linc00511 promotes osteosarcoma cell proliferation and migration through sponging miR-765. |
External Links
| Links for LINC00511 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |