Detail

Basic Information

LncRNA/CircRNA Name	LINC00511
Synonyms	LINC00511, LCAL5, onco-lncRNA-12
Region	GRCh38_17:72323123-72640472
Ensemble	ENSG00000227036
Refseq	NR_033876

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	lung cancer
ICD-0-3	C34
Methods	qPCR, Western blot, RNAi, other
Sample	lung cancer cell lines
Expression Pattern	down-regulated
Function Description	Western blot results showed that silencing LINC00511 inhibited epithelial-mesenchymal transition (EMT), which resulted in decreased expression levels of ZEB2, N-cadherin, and vimentin and increased expression levels of E-cadherin. Additionally, silencing LINC00511 significantly upregulated PTEN mRNA and protein expression, increased FOXO1, and inactivated AKT. Furthermore, we found that PTEN knockdown reversed the inhibition of cell migration and proliferation induced by LINC00511 siRNA, markedly reduced p-FOXO1 expression, and promoted p-AKT expression and EMT in A549 and H460 cells. Therefore, these findings revealed that LINC00511 functions as an oncogene through the PTEN-AKT-FOXO1 signaling pathway in lung cancer, providing a potential target of metastasis in lung cancer.
Pubmed ID	31415720
Year	2019
Title	Silencing LINC00511 Inhibits Cell Proliferation, Migration, and Epithelial-Mesenchymal Transition via the PTEN-AKT-FOXO1 Signaling Pathway in Lung Cancer

External Links

Links for LINC00511	GenBank HGNC NONCODE
Links for lung cancer	OMIM COSMIC