Basic Information
| LncRNA/CircRNA Name | LINC00511 |
| Synonyms | NA |
| Region | GRCh38_17:72323123-72640472 |
| Ensemble | ENSG00000227036 |
| Refseq | NR_033876 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot |
| Sample | bladder cancer tissues, cell line (SV-HUC-1, BIU87, T24, 5637) |
| Expression Pattern | up-regulated |
| Function Description | we demonstrated that linc00511 was highly expressed in bladder cancer tissues and cells. Linc00511 knockdown could cause the cell proliferation suppression and cell cycle arrest. Suppressed linc00511 could induce the apoptosis in T24 and BIU87 cells via activating the caspase pathway. we found that the expression of linc00511 was negatively correlated with that of miR-15a-3p in the clinical bladder cancer samples. All these results indicated that linc00511 promoted the migration and invasion of bladder cancer cells. |
| Pubmed ID | 30042171 |
| Year | 2018 |
| Title | Knockdown of Long Non-Coding RNA linc00511 Suppresses Proliferation and Promotes Apoptosis of Bladder Cancer Cells via Suppressing Wnt/?-catenin Signaling Pathway. |
External Links
| Links for LINC00511 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |