Basic Information
| LncRNA/CircRNA Name | LINC00511 |
| Synonyms | NA |
| Region | GRCh38_17:72323123-72640472 |
| Ensemble | ENSG00000227036 |
| Refseq | NR_033876 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Paclitaxel | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | breast cancer tissues and their corresponding adjacent non-tumor tissues ,breast cancer cell lines (MDA-MB-231, MCF-7, Hs-578T, and T47D) and immortalized breast epithelial cell line MCF-10A |
| Expression Pattern | up-regulated |
| Function Description | LINC00511 and CDK6 were upregulated while miR-29c was downregulated in breast cancer tissues and cells.LINC00511 knockdown enhanced paclitaxel cytotoxicity in breast cancer cells by upregulating miR-29c.LINC00511 knockdown enhanced paclitaxel cytotoxicity in breast cancer cells via regulating miR-29c/CDK6 axis. |
| Pubmed ID | 31047896 |
| Year | 2019 |
| Title | LINC00511 Knockdown Enhances Paclitaxel Cytotoxicity in Breast Cancer via Regulating miR-29c/CDK6 Axis |
External Links
| Links for LINC00511 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |