Basic Information
| LncRNA/CircRNA Name | LINC00511 |
| Synonyms | NA |
| Region | GRCh38_17:72323123-72640472 |
| Ensemble | ENSG00000227036 |
| Refseq | NR_033876 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Luciferase reporter assay , RIP , in vitro knockdown etc. |
| Sample | HCC and matched normal tissues ,LO2 (normal liver cells) and liver cancer cell lines (Hep3B, HepG2, SMMC-7721, MHCC97H,Huh7, and HCCLM3) |
| Expression Pattern | up-regulated |
| Function Description | LINC00511 expression was significantly up-regulated in HCC tissues and cell lines, and its high expression was distinctly associated with nodal metastasis, vascular invasion, and clinical stage.Furthermore, HCC patients with higher LINC00511 expression levels had worse overall survival rates.Importantly, LINC00511 expression was an independent prognostic factor of the overall survival in patients with HCC.Functionally, the inhibition of LINC00511 significantly suppressed the capability of proliferation, migration, and invasion in HCC cell lines.miR-424 both targeted the 3'-UTR of LINC00511,. |
| Pubmed ID | 31081082 |
| Year | 2019 |
| Title | Increased Long Noncoding RNA LINC00511 Is Correlated With Poor Prognosis and Contributes to Cell Proliferation and Metastasis by Modulating miR-424 in Hepatocellular Carcinoma |
External Links
| Links for LINC00511 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |