Basic Information
| LncRNA/CircRNA Name | LINC00511 |
| Synonyms | NA |
| Region | GRCh38_17:72323123-72640472 |
| Ensemble | ENSG00000227036 |
| Refseq | NR_033876 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | human thyroid cancer cell lines (TPC-1, BCPAP and IHH- 4) ,normal thyroid epithelial cell (Nthy-ori 3-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC00511 was significantly overexpressed in thyroid carcinoma and its silencing boosted radiosensitivity of thyroid carcinoma cells.LINC00511 regulated JAK2/STAT3 signaling pathway which was resistant to radiation treatment.Besides, TAF1 modulated JAK2 at transcriptional level. Moreover, LINC00511 bound to TAF1 and further promoted JAK2 expression. In conclusion, rescue experiments verified that the radiosensitivity of thyroid carcinoma cells was attributed to LINC00511/TAF1/JAK2/STAT3 axis. |
| Pubmed ID | 31135274 |
| Year | 2019 |
| Title | Knockdown of LINC00511 Promotes Radiosensitivity of Thyroid Carcinoma Cells via Suppressing JAK2/STAT3 Signaling Pathway |
External Links
| Links for LINC00511 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |