Basic Information
| LncRNA/CircRNA Name | LINC00511 |
| Synonyms | NA |
| Region | GRCh38_17:72323123-72640472 |
| Ensemble | ENSG00000227036 |
| Refseq | NR_033876 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot, RIP, Luciferase reporter assay |
| Sample | Gastric cancer specimens,gastric mucosa epithelial cell (GES1) and gastric cancer cells (HGC27, BGC823, MGC803 and SGC7901) |
| Expression Pattern | up-regulated |
| Function Description | LINC00511 was discovered significantly high in expression in GC tissues and cell lines. Moreover, LINC00511 showed a strong expression in I/II and III/IV stage. Knockdown of LINC00511 could inhibit the cell proliferation while enhanced cell apoptosis rate in GC.down-regulation of LINC00511 could reduce the Ki67 expression and NFIX while lifted the expression of miR-625-5p. |
| Pubmed ID | 31889903 |
| Year | 2019 |
| Title | LINC00511 Accelerated the Process of Gastric Cancer by Targeting miR-625-5p/NFIX Axis |
External Links
| Links for LINC00511 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |