Basic Information
| LncRNA/CircRNA Name | LINC00511 |
| Synonyms | NA |
| Region | GRCh38_17:72323123-72640472 |
| Ensemble | ENSG00000227036 |
| Refseq | NR_033876 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blotting |
| Sample | PTC tissues,thyroid cancer cell lines (B-CPAP, KTC-1, and KTC-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC00511's expression in PTC tissues and cell lines is higher than the control. LINC00511 promoted cellular proliferation, migration, invasion, G1/S transition and reduced apoptosis in vitro experiment. Knocked-down of LINC00511 resulted in the reduction of histone methyltransferase enhancer of zeste homolog 2 (EZH2), cyclin-dependent kinase 2 (CDK2) and cyclin-dependent kinase 4 (CDK4). |
| Pubmed ID | 31897240 |
| Year | 2020 |
| Title | LINC00511 Influences Cellular Proliferation Through Cyclin-Dependent Kinases in Papillary Thyroid Carcinoma |
External Links
| Links for LINC00511 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |