Basic Information
| LncRNA/CircRNA Name | LINC00504 |
| Synonyms | NA |
| Region | GRCh38_4:14470465-14888169 |
| Ensemble | ENSG00000248360 |
| Refseq | NR_126435 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qRT-PCR etc. |
| Sample | The colon cancer cell lines (SW480, HT-29, Caco-2, RKO, and HCT116) and the normal human colon FHC cells |
| Expression Pattern | up-regulated |
| Function Description | The lncRNA LINC00504 was markedly upregulated in colon cancer cell lines and specimens. LINC00504 increases viability and migration of colon cells in vitro. Furthermore, LINC00504 also enhances colon cancer xenograft tumors in vivo. We noted that LINC00504 regulates metabolism at a transcriptional level which influences multiple metabolic pathways, such as glucose metabolism, pentose phosphate pathway, and tricarboxylic acid cycle. Mechanistic study showed that LINC00504 could interact with c-Myc to promote chromatin recruitment of c-Myc and enhance its transactivation activity. |
| Pubmed ID | 30998289 |
| Year | 2019 |
| Title | A Noncoding RNA LINC00504 Interacts With c-Myc to Regulate Tumor Metabolism in Colon Cancer |
External Links
| Links for LINC00504 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |