Basic Information
| LncRNA/CircRNA Name | LINC00483 |
| Synonyms | C17orf73, FLJ20694 |
| Region | GRCh38_17:50761029-50767557 |
| Ensemble | ENSG00000167117 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | gastric cancer tissues, cell lines (SGC7901, BGC823, MGC803, MNK28 and GES-1) |
| Expression Pattern | up-regulated |
| Function Description | linc00483 promoted gastric cancer cell proliferation,invasiveness and metastasis in vitro and in vivo.Mechanistically, upregulated expression of linc00483 in gastric cancer acts as a sponge to absorb endogenous tumour suppressor miR-30a-3p. Furthermore,it restores SPAG9 expression, which is negatively regulated by miR-30a-3p,and actives MAPK signaling pathway in gastric cancer cells.Thus,linc00483 is an oncogenic lncRNA in gastric cancer and targeting linc00483 or its pathway can potentially be useful in development of targeted therapies for patients with gastric cancer.linc00483 is an important regulator in carcinogenesis and may be a useful biomarker to predict prognosis of gastric cancer patients.Linc00483 regulates SPAG9 by acting as a ceRNA and interacting with miR-30a-3p. |
| Pubmed ID | 29761936 |
| Year | 2018 |
| Title | Linc00483 as ceRNA regulates proliferation and apoptosis through activating MAPKs in gastric cancer. |
External Links
| Links for LINC00483 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |