Basic Information
| LncRNA/CircRNA Name | LINC00483 |
| Synonyms | C17orf73, FLJ20694 |
| Region | GRCh38_17:50761029-50767557 |
| Ensemble | ENSG00000167117 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | gastric cancer tissues and matched adjacent normal tissues,cell lines (AGS, MKN-74, MKN-45 and MGC-803) |
| Expression Pattern | up-regulated |
| Function Description | LINC00483 and MAPK1 levels were increased in gastric cancer tissues and cells. Knockdown of LINC00483 or MAPK1 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. Moreover, MAPK1 overexpression attenuated the effect of LINC00483 knockdown on gastric cancer development. LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483. |
| Pubmed ID | 32293550 |
| Year | 2020 |
| Title | LncRNA LINC00483??romotes gastric cancer development through regulating MAPK1 expression by sponging miR-490-3p |
External Links
| Links for LINC00483 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |