Basic Information
| LncRNA/CircRNA Name | LINC00477? |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | RT-PCR , RIP , RNAi etc. |
| Sample | gastric mucosal epithelium from ulcer patients,squamous carcinoma and adenocarcinoma of stomach , their corresponding para-carcinoma tissues ,Gastric cancer cell lines MKN-45, AGS and KATO III,gastric epithelial cells GES-1 |
| Expression Pattern | down-regulated |
| Function Description | The overall expression of LINC00477 was reduced in gastric cancers compared to normal gastric tissues. The isoform 1 of LINC00477 was down-regulated while the isoform 2 was up-regulated in gastric cancer cells. The opposite role of isoforms 1 and 2 in the proliferation and migration of cancer cells in vitro and in vivo was observed. Furthermore, isoform 1 of LINC00477 was determined to interact with ACO1 and suppress the conversion ability from citrate to isocitrate by ACO1. |
| Pubmed ID | 31191018 |
| Year | 2019 |
| Title | The opposite role of alternatively spliced isoforms of LINC00477 in gastric cancer |
External Links
| Links for LINC00477? | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |