Basic Information
| LncRNA/CircRNA Name | ANRIL |
| Synonyms | CDKN2B-AS1, ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS |
| Region | GRCh38_9:21994778-22121097 |
| Ensemble | ENSG00000240498 |
| Refseq | NR_003529 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | ESCC tissues, cell lines (TE1, ECA109) |
| Expression Pattern | up-regulated |
| Function Description | Compared with matched adjacent non-tumor tissues, the expression levels of ANRIL in ESCC tissues were significantly increased. Furthermore, inhibition of ANRIL was found to increase the expression of p15(INK4b) and TGFB1 and depletion of ANRIL in ESCC cell lines may inhibit cellular proliferation. |
| Pubmed ID | 24747824 |
| Year | 2014 |
| Title | ANRIL inhibits p15(INK4b) through the TGFB1 signaling pathway in human esophageal squamous cell carcinoma. |
External Links
| Links for ANRIL | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |