Basic Information
| LncRNA/CircRNA Name | LINC00473 |
| Synonyms | LINC00473, C6orf176, bA142J11.1 |
| Region | GRCh38_6:165908802-165988048 |
| Ensemble | ENSG00000223414 |
| Refseq | NR_026860 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | Microarray, qPCR, RNA-ISH, FISH etc. |
| Sample | lung cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | We discovered that LINC00473 is consistently the most highly induced gene in LKB1-inactivated human primary NSCLC samples and derived cell lines. Elevated LINC00473 expression correlated with poor prognosis, and sustained LINC00473 expression was required for the growth and survival of LKB1-inactivated NSCLC cells. Mechanistically, LINC00473 was induced by LKB1 inactivation and subsequent cyclic AMP-responsive element-binding protein (CREB)/CREB-regulated transcription coactivator (CRTC) activation. We determined that LINC00473 is a nuclear lncRNA and interacts with NONO, a component of the cAMP signaling pathway, thereby facilitating CRTC/CREB-mediated transcription |
| Pubmed ID | 27140397 |
| Year | 2016 |
| Title | cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth |
External Links
| Links for LINC00473 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |