Basic Information
| LncRNA/CircRNA Name | LINC00473 |
| Synonyms | LINC00473, C6orf176, bA142J11.1 |
| Region | GRCh38_6:165908802-165988048 |
| Ensemble | ENSG00000223414 |
| Refseq | NR_026860 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blotting etc. |
| Sample | cell lines (SiHa, HeLa, Caski, C4-1, C-33a) |
| Expression Pattern | up-regulated |
| Function Description | LINC00473 promoted cell proliferation and inhibited cell apoptosis in cervical cancer cells in vitro. Moreover, we found that LINC00473 enhanced the growth of cervical cancer cells in vivo. Mechanistic investigation showed that LINC00473 directly interacted with ILF2 and suppressed its degradation. Finally, we demonstrated that miR-34a reduced the stability of LINC00473. These fndings may have important implications for developing novel therapeutic strategies for cervical cancer.Patients with higher LINC00473 levels had shorter overall survival time than those with lower LINC00473 levels. |
| Pubmed ID | 29218240 |
| Year | 2017 |
| Title | The long noncoding RNA LINC00473, a target of microRNA 34a, promotes tumorigenesis by inhibiting ILF2 degradation in cervical cancer |
External Links
| Links for LINC00473 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |