Basic Information
| LncRNA/CircRNA Name | LINC00473 |
| Synonyms | NA |
| Region | GRCh38_6:165908802-165988048 |
| Ensemble | ENSG00000223414 |
| Refseq | NR_026860 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | taxol | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, luciferase reporter assay |
| Sample | colorectal cancer tissues, cell lines (HCT116,HCT116/ Taxol, SW620, LoVo, FHC) |
| Expression Pattern | up-regulated |
| Function Description | LINC00473 was overexpressed in CRC tissues when compared with which in normal tissues. LINC00473 harbored the binding sites for miR-15a and reduced its availability in CRC cell line HCT116. Knockdown of LINC00473 restored the Taxol-induced cytotoxicity, inhibited the cell vitality, colony formation and induced apoptosis, impaired the ability of migration or invasion. |
| Pubmed ID | 30126852 |
| Year | 2018 |
| Title | LINC00473 promotes the Taxol resistance via miR-15a in colorectal cancer. |
External Links
| Links for LINC00473 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |