Basic Information
| LncRNA/CircRNA Name | LINC00473 |
| Synonyms | NA |
| Region | GRCh38_6:165908802-165988048 |
| Ensemble | ENSG00000223414 |
| Refseq | NR_026860 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | Dual luciferase reporter assay, RIP, RT-qPCR, Western blotting |
| Sample | glioma tissues,glioma cell lines (U251, U118, LN229, U87 and SHG44) and a normal human astrocyte cell line (NHA) |
| Expression Pattern | up-regulated |
| Function Description | LINC00473 was significantly increased in glioma tissues and in cell models, and predicted a poor prognosis in patients with glioma. Notably, LINC00473 knockdown not only suppressed cell proliferation, invasion and migration of glioma cells, but also blocked cell cycle progression and induced apoptosis. Subcutaneous xenotransplanted tumor model experiments revealed that reduced LINC00473 expression was able to suppress in vivo glioma growth. Mechanistically, LINC00473 functioned as a competing endogenous (ce)RNA to decrease microRNA (miR)-195-5p expression. |
| Pubmed ID | 31894297 |
| Year | 2020 |
| Title | Long Non-coding RNA LINC00473/miR-195-5p Promotes Glioma Progression via YAP1-TEAD1-Hippo Signaling |
External Links
| Links for LINC00473 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |