Basic Information
| LncRNA/CircRNA Name | LINC00472 |
| Synonyms | LINC00472, C6orf155 |
| Region | GRCh38_6:71344344-71420769 |
| Ensemble | ENSG00000233237 |
| Refseq | NR_121612 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Cell proliferation assay, Cell migration assay etc. |
| Sample | cell lines (MCF7 and SKBR3) |
| Expression Pattern | down-regulated |
| Function Description | Our qPCR results showed that high LINC00472 expression was associated with less aggressive breast tumors and more favorable disease outcomes. Patients with high expression of LINC00472 had significantly reduced risk of relapse and death compared to those with low expression. Cell culture experiments showed that up-regulation of LINC00472 expression could suppress breast cancer cell proliferation and migration. |
| Pubmed ID | 25865225 |
| Year | 2015 |
| Title | Prognostic and predictive values of long non-coding RNA LINC00472 in breast cancer. |
External Links
| Links for LINC00472 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |