Basic Information
| LncRNA/CircRNA Name | LINC00472 |
| Synonyms | LINC00472, C6orf155 |
| Region | GRCh38_6:71344344-71420769 |
| Ensemble | ENSG00000233237 |
| Refseq | NR_121612 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR etc. |
| Sample | colorectal cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | LINC00472 was verified to be downregulated in CRC cell lines and cancer tissues compared with adjacent tissues. In addition, the down-regulation of LINC00472 seemed to be caused by DNA hypermethylation at its promoter region. Furthermore, the expression of LINC00472 and DNA methylation of promoter were significantly correlated with clinicopathological features. And DNA hypermethylation of LINC00472 may serve as a better diagnostic biomarker than its expression for CRC. Finally, we predicted the functions of LINC00472 and constructed a regulatory network and found LINC00472 may be involved in cell cycle and cell proliferation processes. |
| Pubmed ID | 29488624 |
| Year | 2018 |
| Title | Regulatory network analysis of LINC00472, a long noncoding RNA downregulated by DNA hypermethylation in colorectal cancer. |
External Links
| Links for LINC00472 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |