Basic Information
| LncRNA/CircRNA Name | LINC00472 |
| Synonyms | NA |
| Region | GRCh38_6:71344344-71420769 |
| Ensemble | ENSG00000233237 |
| Refseq | NR_121612 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | NSCLC cell lines, NCIH838, NCI-H1975, NCI-H157, NCI-H358, and NCI-H1299 cells, human normal lung epithelial cell line (BEAS-2B), NSCLC tissue, adjacent normal tissue |
| Expression Pattern | down-regulated |
| Function Description | LINC00472 and KLLN were found to exhibit low levels, while miR-149-3p and miR-4270 were highly expressed in NSCLC. In addition, the overexpression of LINC00472 was observed to upregulate KLLN and activate the p53-signaling pathway, which ultimately inhibited the invasion, migration, and EMT of NSCLC cells via miR-149-3p and miR-4270, corresponding to decreased N-cadherin and Vimentin and increased E-cadherin. The overexpression of LINC00472 exerted an inhibitory effect on tumor growth in vivo. |
| Pubmed ID | 31382188 |
| Year | 2019 |
| Title | LINC00472 Acts as a Tumor Suppressor in NSCLC through KLLN-Mediated p53-Signaling Pathway via MicroRNA-149-3p and MicroRNA-4270 |
External Links
| Links for LINC00472 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |