Basic Information
| LncRNA/CircRNA Name | LINC00472 |
| Synonyms | NA |
| Region | GRCh38_6:71344344-71420769 |
| Ensemble | ENSG00000233237 |
| Refseq | NR_121612 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | OS tissues, cell lines(HFOB1.19, KHOS, MG63, U2OS, HOS, and Saos-2) |
| Expression Pattern | down-regulated |
| Function Description | The expressions of LINC00472 were inhibited in OS tissues and cells, and were negatively related to the expressions of miR-300. LINC00472 directly targeted miR-300. FOXO1 was inhibited in OS tissues and its expressions were negatively related to the expressions of miR-300. |
| Pubmed ID | 32256209 |
| Year | 2020 |
| Title | Down-regulation of LINC00472 promotes osteosarcoma tumorigenesis by reducing FOXO1 expressions via miR-300 |
External Links
| Links for LINC00472 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |