Basic Information
| LncRNA/CircRNA Name | LINC00470 |
| Synonyms | NA |
| Region | GRCh38_18:1254383-1408344 |
| Ensemble | ENSG00000132204 |
| Refseq | NR_023925 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | HCC and matched adjacent normal tissue ,immortalized normal liver cell line LO2 and HCC cell lines(Hep3B, SK-Hep-1, SMMC-7721, Huh7, PLC/PRF/5 and HepG2 ) |
| Expression Pattern | up-regulated |
| Function Description | LINC00470 was upregulated in HCC cells and tissues. High-level LINC00470 was significantly correlated with bigger tumor size, advanced TNM stage and poor prognosis in patients with HCC.Knockdown of LINC00470 expression inhibited HCC cell proliferation and cell cycle progression.LINC00470 was associated with NF45/NF90 complex and increased its interaction with cyclin E1 mRNA, thus inhibiting the degradation of cyclin E1 mRNA.Additionally, knockdown of cyclin E1 in LINC00470-overexpressed cells abolished its promotive effects on HCC cell proliferation. |
| Pubmed ID | 31612313 |
| Year | 2019 |
| Title | LncRNA LINC00470 Promotes Proliferation Through Association With NF45/NF90 Complex in Hepatocellular Carcinoma |
External Links
| Links for LINC00470 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |