Basic Information
| LncRNA/CircRNA Name | LINC00470 |
| Synonyms | NA |
| Region | GRCh38_18:1254383-1408344 |
| Ensemble | ENSG00000132204 |
| Refseq | NR_023925 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | glioblastoma tissues, cell lines (U251 and U87) |
| Expression Pattern | up-regulated |
| Function Description | The levels of LINC00470 were significantly increased in astrocytoma tissues compared with normal brain tissues by RT-qPCR. Overexpression of LINC00470 contributed to the proliferation of PG1 and PG2 cells by CCK-8 assay. LINC00470 was a positive regulator for AKT activation in GBM. LINC00470 bound to FUS and AKT to form a ternary complex, anchoring FUS in the cytoplasm to increase AKT activity. Higher pAKT activated by LINC00470 inhibited ubiquitination of HK1, which affected glycolysis, and inhibited cell autophagy. Furthermore, higher LINC00470 expression was associated with GBM tumorigenesis and poor patient prognosis. |
| Pubmed ID | 29866190 |
| Year | 2018 |
| Title | A Cytoplasmic Long Noncoding RNA LINC00470 as a New AKT Activator to Mediate Glioblastoma Cell Autophagy |
External Links
| Links for LINC00470 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |