Basic Information
| LncRNA/CircRNA Name | LINC00467 |
| Synonyms | NA |
| Region | GRCh38_1:211382803-211435333 |
| Ensemble | ENSG00000153363 |
| Refseq | NR_026761 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blot analysis, Dual luciferase reporter assay, RIP |
| Sample | HCC tissues,HCC cell lines Bel-7402, SMMC-7721, HepG2, Hep3B, HCCLM3, and normal liver cell line LO2 |
| Expression Pattern | up-regulated |
| Function Description | linc00467 was upregulated in HCC tissues and cells. Silencing of linc00467 using small interfering RNA interference significantly inhibited the growth and motility of HCC cells, and increased cell apoptosis through regulating the Bcl-2/Bax axis and the caspase cascade, suggesting that linc00467 exerted oncogenic functions in the progression of HCC.linc00467 could target miR-18a-5p. |
| Pubmed ID | 31916278 |
| Year | 2020 |
| Title | Long Noncoding RNA linc00467 Plays an Oncogenic Role in Hepatocellular Carcinoma by Regulating the miR-18a-5p/NEDD9 Axis |
External Links
| Links for LINC00467 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |