Basic Information
LncRNA/CircRNA Name | ANRIL |
Synonyms | CDKN2B-AS1, ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS |
Region | GRCh38_9:21994778-22121097 |
Ensemble | ENSG00000240498 |
Refseq | NR_003529 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | apoptosis | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | thyroid cancer |
ICD-0-3 | C73.9 |
Methods | qPCR, RNAi, Western blot etc. |
Sample | thyroid cancer tissues, cell lines (K1, TPC-1, SW579 and Nthy-ori 3-1) |
Expression Pattern | up-regulated |
Function Description | The results of qRT-PCR showed significantly higher expression of ANRIL mRNA in the TC tissues relative to the adjacent normal tissues. ANRIL may reduce p15INK4B expression through inhibiting TGF-B/Smad signaling pathway, promoting invasion and metastasis of TC cells, and the silencing of ANRIL inhibits the invasion and metastasis of TPC-1 cells. |
Pubmed ID | 27507052 |
Year | 2016 |
Title | Long non-coding RNA ANRIL promotes the invasion and metastasis of thyroid cancer cells through TGF-B/Smad signaling pathway. |
External Links
Links for ANRIL | GenBank HGNC NONCODE |
Links for thyroid cancer | OMIM COSMIC |