Basic Information
| LncRNA/CircRNA Name | LINC00467 |
| Synonyms | NA |
| Region | GRCh38_1:211382803-211435333 |
| Ensemble | ENSG00000153363 |
| Refseq | NR_026761 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Axitinib | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc |
| Sample | cell lines (MHCC97H, Hep3B, HepG2, Huh7, and HCCLM3) |
| Expression Pattern | up-regulated |
| Function Description | LINC00467 was upregulated in HCC samples in TCGA database, and was confirmed to be elevated in HCC cell lines. Functionally, LINC00467 depletion impeded proliferation and invasion, induced apoptosis, and promoted cellular sensitivity to Axitinib in HCC. Mechanistically, LINC00467 performed as a sponge of microRNA (miR)-509-3p and upregulated the expression of platelet-derived growth factor receptor alpha (PDGFRA) in HCC cells. |
| Pubmed ID | 32221502 |
| Year | 2020 |
| Title | Knockdown of LINC00467 Contributed to Axitinib Sensitivity in Hepatocellular Carcinoma Through miR-509-3p/PDGFRA Axis |
External Links
| Links for LINC00467 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |