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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	breast cancer
ICD-0-3	C50
Methods	qPCR, Western blot, Luciferase reporter assay, RIP, etc.
Sample	BC tissues, normal human breast epithelial cell line MCF-10A and BC cell lines (MDA-MB-468, MDA-MB-231, MDAMB-415, and MCF7)
Expression Pattern	up-regulated
Function Description	LINC00461 was found to be significantly upregulated in both BC tissues and cell lines. Besides, we found that high LINC00461 expression was associated with TNM stage and differentiation. Furthermore, functional studies demonstrated that LINC00461 expedited BC cell migration and invasion. Notably, LINC00461 was observed to enhance the expression of vimentin and zinc finger E box binding homeobox factor 1, suppress the expression of E cadherin, and promote the activation of extracellular signal regulated kinase and AKT signaling pathways. Mechanical investigations revealed that LINC00461 positively modulated integrin ?3 (ITGB3) expression as miR 30a 5p sponge in BC cells. Taken together, LINC00461 exerts an oncogenic role in BC through miR 30a 5p/ITGB3 axis.
Pubmed ID	30623482
Year	2019
Title	LINC00461 promotes cell migration and invasion in breast cancer through miR-30a-5p/integrin ?3 axis.

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