Basic Information
| LncRNA/CircRNA Name | LINC00461 |
| Synonyms | NA |
| Region | GRCh38_5:88507546-88691041 |
| Ensemble | ENSG00000245526 |
| Refseq | NR_024384 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | multiple myeloma |
| ICD-0-3 | C42.1 |
| Methods | qPCR, Luciferase reporter assay, RIP, Western blot , other |
| Sample | plasma cells |
| Expression Pattern | up-regulated |
| Function Description | LINC00461 was highly expressed in MM. Knockdown of LINC00461 dramatically reduced MM cell proliferation and induced cell apoptosis. Further study showed that LINC00461 relieved the inhibitory effect of microRNA (miR)-15a/miR-16 on BCL-2. In addition, we observed that MSC-derived exosomes promoted MM cell proliferation through LINC00461. |
| Pubmed ID | 30409700 |
| Year | 2019 |
| Title | Exosome-transmitted LINC00461 Promotes Multiple Myeloma Cell Proliferation and Suppresses Apoptosis by Modulating microRNA/BCL-2 Expression |
External Links
| Links for LINC00461 | GenBank HGNC NONCODE |
| Links for multiple myeloma | OMIM COSMIC |