Basic Information
| LncRNA/CircRNA Name | LINC00461 |
| Synonyms | NA |
| Region | GRCh38_5:88507546-88691041 |
| Ensemble | ENSG00000245526 |
| Refseq | NR_024384 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Dual luciferase reporter assay, Western blot |
| Sample | Colorectal cancer tumor tissues,normal colonic epithelial cell NCM460, colonic cancer cell lines (DLD-1, RKO, HT29, and SW480) and HEK293T |
| Expression Pattern | up-regulated |
| Function Description | the expression of LINC00461 was significantly overexpressed in CRC tissues and different cell lines, and the high level of LINC00461 expression was associated with poor overall survival. Downregulation of LINC00461 expression significantly suppressed the proliferation, migration and invasion of CRC cells and promoted cell apoptosis. We also found that LINC00461 could directly interact with miR-323b-3p. In addition, LINC00461 significantly increased the expression NFIB and CDK2, but, p21 was inhibited. |
| Pubmed ID | 31908480 |
| Year | 2019 |
| Title | LncRNA LINC00461 Promotes Colorectal Cancer Progression via miRNA-323b-3p/NFIB Axis |
External Links
| Links for LINC00461 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |