Basic Information
| LncRNA/CircRNA Name | LINC00460 |
| Synonyms | NA |
| Region | GRCh38_13:106374477-106384315 |
| Ensemble | ENSG00000233532 |
| Refseq | NR_034119 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | PTC tissues, human PTC cell lines TPC-1, BCPAP, and IHH-4 and the normal thyroid epithelial cell line (Nthy-ori 3-1) |
| Expression Pattern | up-regulated |
| Function Description | the level of LINC00460 was significantly upregulated in PTC tissues and cell lines, which was positively correlated with advanced tumor node metastasis (TNM) stage and lymph node metastasis. Cellular experiments exhibited that knockdown of LINC00460 decreased proliferative, migratory, and invasive abilities of PTC cells. Mechanism assays noted that knockdown of LINC00460 suppressed cell proliferation, migration, and invasion, and inhibited expression of sphingosine kinase 2 (SphK2, a target of miR 613) in PTC cells, at least in part, by regulating miR 613. These findings suggested that LINC00460 could function as a competing endogenous RNA to regulate SphK2 expression by sponging miR 613 in PTC. |
| Pubmed ID | 30478856 |
| Year | 2018 |
| Title | Long noncodingRNA LINC00460 promotes carcinogenesis via sponging miR-613 in papillary thyroid carcinoma |
External Links
| Links for LINC00460 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |