Basic Information
| LncRNA/CircRNA Name | LINC00460 |
| Synonyms | NA |
| Region | GRCh38_13:106374477-106384315 |
| Ensemble | ENSG00000233532 |
| Refseq | NR_034119 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | tumor tissue,cell lines (HepG2, Huh7, SMMC7721, BEL-7402, HCCLM3, SK-HEP-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC00460 expression was significantly upregulated in both HCC tumor tissues and cell lines. The upregulation of LINC00460 was positively associated with HCC progression. Functionally, LINC00460 facilitated HCC cell proliferation, migration, and invasion capacities, which due to that LINC00460 could physically bind to and repress miR-342-3p to elevate the expression of AGR2. |
| Pubmed ID | 32184630 |
| Year | 2020 |
| Title | Long Noncoding RNA LINC00460 Promotes Hepatocellular Carcinoma Progression via Regulation of miR-342-3p/AGR2 Axis |
External Links
| Links for LINC00460 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |