Basic Information
| LncRNA/CircRNA Name | LINC00460 |
| Synonyms | NA |
| Region | GRCh38_13:106374477-106384315 |
| Ensemble | ENSG00000233532 |
| Refseq | NR_034119 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot |
| Sample | PTC tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | LINC00460 can modulate MMP-9 expression to promote cell proliferation, invasion and apoptosis through targeting miR-539, suggesting act as an oncogenic RNA in PTC and provide a new therapeutic perspective. |
| Pubmed ID | 32021436 |
| Year | 2020 |
| Title | Long Noncoding RNA LINC00460 Modulates MMP-9 to Promote Cell Proliferation, Invasion and Apoptosis by Targeting miR-539 in Papillary Thyroid Cancer |
External Links
| Links for LINC00460 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |