Basic Information
| LncRNA/CircRNA Name | LINC00460 |
| Synonyms | NA |
| Region | GRCh38_13:106374477-106384315 |
| Ensemble | ENSG00000233532 |
| Refseq | NR_034119 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot |
| Sample | GC tissues, cell lines |
| Expression Pattern | up-regulated |
| Function Description | LINC00460 promoted GC proliferation at least partly through the downregulation of tumor suppressor-gene Cyclin G2 (CCNG2), which is mediated by EZH2 and LSD1.LINC00460 acted as an oncogene in GC to inhibit the expression of CCNG2 at least partly by binding with EZH2 and LSD1. |
| Pubmed ID | 32059342 |
| Year | 2019 |
| Title | Upregulation of lncRNA LINC00460 Facilitates GC Progression through Epigenetically Silencing CCNG2byEZH2/LSD1 and Indicates Poor Outcomes |
External Links
| Links for LINC00460 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |