Basic Information
| LncRNA/CircRNA Name | LINC00441 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP, etc. |
| Sample | GC tumor tissues, HGC-27 ,AGS cells ,SGC-7901 ,KATO III cells ,MGC-803 and NCI-N87 cells |
| Expression Pattern | up-regulated |
| Function Description | the up-regulated Linc00441 was inversely correlated with RB1 expression in human GC tumor samples. The gain- and loss-of-function investigation revealed that Linc00441 could promote the proliferation of GC cells. Furthermore, RNA pull down and RIP assays demonstrated that Linc00441 could recruit DNMT1 to the RB1 promoter and suppressed RB1 expression in GC cells. In conclusion, our findings revealed that Linc00441 played crucial role in GC progression and suggested that Linc00441 was potentially an effective target for GC therapy in the future. |
| Pubmed ID | 30680063 |
| Year | 2018 |
| Title | Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer |
External Links
| Links for LINC00441 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |