Basic Information
| LncRNA/CircRNA Name | LINC00355 |
| Synonyms | NA |
| Region | GRCh38_13:63986371-64076011 |
| Ensemble | ENSG00000227674 |
| Refseq | NR_145420 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | Dual luciferase reporter gene assay, RIP, RT-qPCR, Western blot analysis |
| Sample | tumor tissue samples,lung adenocarcinoma cell lines including A549, H1299, H292, PC-9, H460 and LK2 and normal pulmonary epithelial cell line HBE |
| Expression Pattern | up-regulated |
| Function Description | increased LINC00355 expressions in lung adenocarcinoma tissues and cells.LINC00355 silencing suppressed the proliferation in vitro and in vivo.LINC00355 negatively regulated miR-195 in lung adenocarcinoma cells. Simultaneously, silencing LINC00355 by shRNA resulted in suppressed proliferation, colony formation and promoted cell cycle arrest and apoptosis via miR-195. |
| Pubmed ID | 31689506 |
| Year | 2020 |
| Title | A Novel Long Non-Coding RNA LINC00355 Promotes Proliferation of Lung Adenocarcinoma Cells by Down-Regulating miR-195 and Up-Regulating the Expression of CCNE1 |
External Links
| Links for LINC00355 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |