Basic Information
| LncRNA/CircRNA Name | LINC00337 |
| Synonyms | NA |
| Region | GRCh38_1:6236240-6239444 |
| Ensemble | ENSG00000225077 |
| Refseq | NR_103534 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, RIP |
| Sample | Normal bronchial epithelial cells (NHBE) and NSCLC cell lines (A549, H460, H1299, H322), NSCLC tissue, normal tissue |
| Expression Pattern | up-regulated |
| Function Description | In the NSCLC tissue and cell lines, LINC00337 was found to be remarkedly up-regulated, and the ectopic LINC00337 overexpression indicated the poor survival of NSCLC patients. In vitro, gain and loss of functional assays showed that LINC00337 promoted the progression of NSCLC cells, including proliferation and invasion. In vivo, LINC00337 knockdown inhibited the tumor growth of NSCLC cells. Mechanically, LINC00337 could recruit the epigenetic repressor DNMT1 to the promoter region of TIMP2 to silence its expression. |
| Pubmed ID | 31632575 |
| Year | 2019 |
| Title | Long noncoding RNA LINC00337 accelerates the non-small-cell lung cancer progression through inhibiting TIMP2 by recruiting DNMT1 |
External Links
| Links for LINC00337 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |