Basic Information
| LncRNA/CircRNA Name | LINC00324 |
| Synonyms | NA |
| Region | GRCh38_17:8220642-8224043 |
| Ensemble | ENSG00000178977 |
| Refseq | NR_026951 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | LAC tissues, LAC-derived cell lines (A549, PC-9, H1650, SPCA1, H1299) and human normal lung bronchial epithelial cell line 16HBE |
| Expression Pattern | up-regulated |
| Function Description | LINC00324 was highly expressed in LAC tissues compared with the para-tumor samples. Identically, the expression level of LINC00324 was significantly higher in LAC cell lines. The overexpression of LINC00324 promoted cell proliferation and inhibited cell apoptosis of LAC cells, while knockdown of LINC00324 presented the opposite effect. Up-regulation of LINC00324 accelerated cell migration and invasion, but down-regulation of LINC0324 decreased cell metastasis of LAC cells. Furthermore, miR-615-5p was found to be regulated by LINC00324 and inhibited AKT1 expression, indicating that LINC00324 promoted cell progression via affecting the miR-615-5p/AKT1 pathway. |
| Pubmed ID | 30556874 |
| Year | 2018 |
| Title | LINC00324 exerts tumor-promoting functions in lung adenocarcinoma via targeting miR-615-5p/AKT1 axis |
External Links
| Links for LINC00324 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |