Basic Information
| LncRNA/CircRNA Name | LINC00324 |
| Synonyms | NA |
| Region | GRCh38_17:8220642-8224043 |
| Ensemble | ENSG00000178977 |
| Refseq | NR_026951 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | gastric cancer tissues, cell lines (SGC7901, BGC823, MGC803, AGS and GES-1) |
| Expression Pattern | up-regulated |
| Function Description | The expression level of LINC00324 was significantly upregulated in GC tissues compared with the corresponding normal tissues. The overexpression of LINC00324 was correlated with advanced TNM stage, larger tumor size, and lymph node metastasis as well as poor prognosis. Further experiments revealed that knockdown of LINC00324 could suppress the proliferation and induces apoptosis of GC cells. RNA transcriptome sequencing technology revealed that FAM83B may be a significant downstream target gene of LINC00324. LINC00324 could combine with the RNA-binding protein (RBP) human antigen R (HuR) and thus stabilize the expression of FAM83B. Moreover, rescue assays showed that the reduced FAM83B expression partially reversed the promotion of cell growth in GC induced by the overexpression of LINC00324. |
| Pubmed ID | 29915327 |
| Year | 2018 |
| Title | Long Intergenic Non-Coding RNA 00324 Promotes Gastric Cancer Cell Proliferation via Binding With HuR and Stabilizing FAM83B Expression |
External Links
| Links for LINC00324 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |