Basic Information
| LncRNA/CircRNA Name | LINC00324 |
| Synonyms | NA |
| Region | GRCh38_17:8220642-8224043 |
| Ensemble | ENSG00000178977 |
| Refseq | NR_026951 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | RT-qPCR, Western blot, Microarray |
| Sample | HCC tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | Silencing of LINC00324 or FasL suppressed expression of stemness-related genes, cell viability, proliferation, migration, invasion, self-renewal, and tumorigenesis, but enhanced cell apoptosis. Taken together, LINC00324 promotes the expression of FasL through the recruitment of PU.1, which ultimately maintains the biological properties of LCSCs |
| Pubmed ID | 32128906 |
| Year | 2020 |
| Title | Long noncoding RNA LINC00324 exerts protumorigenic effects on liver cancer stem cells by upregulating fas ligand via PU box binding protein |
External Links
| Links for LINC00324 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |