Basic Information
| LncRNA/CircRNA Name | LINC00320 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | fresh tumor tissues, U251, LN229 and NHE cells |
| Expression Pattern | down-regulated |
| Function Description | a HMGB1 regulated lncRNA, Linc00320, is significantly decreased in Glioma malignant tissues and its low expression predicts poor prognosis. Moreover, we found that the nucleus localized Linc00320 inhibits Glioma cell proliferation both in vitro and in vivo. In addition, we found that Linc00320 binds to b-catenin and inhibits the activity of Wnt/b-catenin signaling by disrupting b-catenin binds to TCF4 in Glioma cells. Taken together, we firstly demonstrated the tumor suppressive lncRNA, Linc00320, is down-regulated in Glioma tissues and inhibits Glioma cell proliferation by restraining Wnt/b-catenin signaling through segregating b-catenin and TCF4 and revealed the novel HMGB1/Linc00320/b-catenin axis in Glioma progression. |
| Pubmed ID | 30503496 |
| Year | 2018 |
| Title | Long non-coding RNA Linc00320 inhibits glioma cell proliferation through restraining Wnt/b-catenin signaling |
External Links
| Links for LINC00320 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |