Basic Information
| LncRNA/CircRNA Name | LINC00319 |
| Synonyms | NA |
| Region | GRCh38_21:43446601-43453893 |
| Ensemble | ENSG00000188660 |
| Refseq | NR_026960 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot |
| Sample | cell lines (PAa, Agi Y-83a, A549, HBE, Anip-973) |
| Expression Pattern | up-regulated |
| Function Description | linc00319 increased the proliferation and invasion of A549 cells,and suppressed cell apoptosis.linc00319 promotes cell proliferation and invasion in lung cancer cells by directly binding with and downregulating the tumor suppressor miR-32.High level of HOTAIR was demonstrated to be correlated with invasion,metastasis,and poor survival in lung cancer patients. |
| Pubmed ID | 28800794 |
| Year | 2017 |
| Title | Long Intergenic Noncoding RNA 319 (linc00319) Promotes Cell Proliferation and Invasion in Lung Cancer Cells by Directly Downregulating the Tumor Suppressor MiR-32. |
External Links
| Links for LINC00319 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |